Qualification of a Single‐Use Disk Stack Separator for Cell Separation in Mammalian Cell‐Based Antibody Production

Single-use technology is now an indispensable part of biopharmaceutical production processes. This not only applies to research and development, but also commercial The manufacturers single-use systems are working on improving them for use in intensified processes as well new developments. One the bottlenecks was availability disk stack separators whose stainless steel variants widely used industry. In this study, suitability separator kytero 500 investigated first time cell separation pilot-scale Chinese hamster ovary cell-based antibody production. cells were completely separated over a wide range settings with nearly no release intracellular substances loss antibody.